| MLB First Round Draft Picks - 2005 | ||||
| PICK | PLAYER | POS | TEAM | SCHOOL/HOMETOWN |
| 1 | Justin Upton | SS | Arizona Diamondbacks | Great Bridge HS (VA) |
| 2 | Alex Gordon | 3B | Kansas City Royals | Nebraska |
| 3 | Jeffrey Clement | C | Seattle Mariners | USC |
| 4 | Ryan Zimmerman | 3B | Washington Nationals | Virginia |
| 5 | Ryan Braun | 3B | Milwaukee Brewers | Miami |
| 6 | Ricardo Romero | LHP | Toronto Blue Jays | CS Fullerton |
| 7 | Troy Tulowitski | SS | Colorado Rockies | Long Beach |
| 8 | Wade Townsend | RHP | Tampa Bay Devil Rays | Rice |
| 9 | Michael Pelfrey | RHP | New York Mets | Wichita St |
| 10 | Cameron Maybin | CF | Detroit Tigers | T C Roberson HS (NC) |
| 11 | Andrew McCutchen | CF | Pittsburgh Pirates | Fort Meade HS (FL) |
| 12 | Jay Bruce | CF | Cincinnati Reds | West Brook HS (TX) |
| 13 | Brandon Snyder | C | Baltimore Orioles | Westfield HS (VA) |
| 14 | Trevor Crowe | CF | Cleveland Indians | Arizona |
| 15 | Lance Broadway | RHP | Chicago White Sox | TCU |
| 16 | Christopher Volstad | RHP | Florida Marlins | Palm Beach Gardens HS (FL) |
| 17 | Carl Henry | SS | New York Yankees | Putnam City HS (OK) |
| 18 | Cesar Carrillo | RHP | San Diego Padres | Miami |
| 19 | John Mayberry | RF | Texas Rangers | Stanford |
| 20 | Mark Pawelek | LHP | Chicago Cubs | Springville HS (UT) |
| 21 | Clifton Pennington | SS | Oakland Athletics | Texas A&M |
| 23 | Jacoby Ellsbury | CF | Boston Red Sox | Oregon St |
| 24 | Brian Bogusevic | LHP | Houston Astros | Tulane |
| 25 | Matthew Albidrez-Garza | RHP | Minnesota Twins | Fresno St |
| 26 | Craig Hansen | RHP | Boston Red Sox | St. Johns |
| 27 | Joseph Devine | RHP | Atlanta Braves | North Carolina St |
| 28 | Colby Rasmus | CF | St. Louis Cardinals | Russell County HS (AL) |
| 30 | James Greene | SS | St. Louis Cardinals | Georgia Tech |