Uruguay's Edinson Cavani scored early and fellow striker Luis Suarez converted a second-half penalty, his fourth in three games for his country, as they beat Colombia 3-0 in Friday's CONMEBOL World Cup qualifier.
Cavani got the opener in the fifth minute after Nahitan Nandez had done the hard work in midfield by robbing the ball and setting him up to fire home a low right-foot shot.
Yerry Mina was sent off for Colombia after a second yellow card in the final minute of the game to complete a miserable afternoon for the home side.
Suarez's goal was his 63rd international strike and came after he scored twice from the penalty spot in Uruguay's 4-2 loss to Ecuador and once in their 2-1 win over Chile in their opening qualifier last month.
The victory takes Uruguay to six points after three games, while Colombia, who beat Venezuela and drew away to Chile in their first two games, have four.
The top four sides in the 10-team South American group qualify automatically for the Qatar 2022 finals and the fifth-placed team go into an inter-regional playoff.
Uruguay now travel home to face Brazil on Tuesday when Colombia will be away to Ecuador.