Part of the return for Seattle is one of San Diego's top prospects, outfielder Taylor Trammell. Other players included in the Mariners' haul are infielder Ty France, catcher Luis Torrens and right-handed relief pitcher Andres Munoz.
Also headed to the Padres are relievers Austin Adams and Dan Altavilla. A big-time right-handed arm who struck out 51 in 31 innings last year, Adams has been recovering from ACL surgery but will return soon and should be a nice addition for San Diego alongside the recently acquired Trevor Rosenthal. Altavilla has been part of Seattle's bullpen since 2016 but has appeared in more than 22 games only once. This season, he is 1-2 with a 7.71 ERA in 13 appearances.
Nola is hitting .306 this season for Seattle, with five home runs and 19 RBIs in 29 games as the team's primary backstop. Last season, he batted .269 with 10 homers and 31 RBIs in 79 games, and played first, second and third base, and both corner outfield positions.
Trammell was dealt by Cincinnati to the Padres last season in a three-way trade involving the Cleveland Indians.
Trammell is rated the Padres' No. 5 prospect and MLB's 75th overall by ESPN's Kiley McDaniel. He hit .234 with 10 home runs, 43 RBIs and 20 stolen bases in 126 games in Double-A last season.
Munoz -- who was considered San Diego's closer of the future before undergoing Tommy John surgery in March -- made his debut in the majors last season. He appeared in 22 games and was regularly clocked above 100 mph with his fastball. He had a 3.91 ERA in 22 appearances.
France has appeared in 20 games this season for the Padres and is hitting .309 with two home runs and 10 RBIs and can play both corner infield positions.
"We are excited to add four talented players to the Mariners organization, all of whom are playing in their age-25 or younger seasons,'' Seattle general manager Jerry Dipoto said in a statement.
The Padres currently have the second-most wins (21) in the National League, trailing only division rival Los Angeles (26). They are looking to end a playoff drought dating to 2006.
San Diego has been busy as Monday's 4 p.m. ET trade deadline approaches, acquiring slugger Mitch Moreland from the Boston Red Sox and veteran catcher Jason Castro from the Los Angeles Angels earlier Sunday. Those moves came on the heels of the Padres making a big splash with their trade for Kansas City's Rosenthal on Saturday.
The Associated Press contributed to this report.