With Brazil into the World Cup and Argentina on the verge, teams such as Ecuador, Colombia, Chile, and Uruguay are fighting for their spots.
Brazil beat Colombia 1-0 in a World Cup qualifier in Sao Paulo on Thursday to become the first South American team to qualify for Qatar 2022.
James Rodriguez has been called back into a Colombia team desperate for some creativity. Elsewhere, Paraguay and Chile face make-or-break games.
Colombia held Brazil to a 0-0 draw in an engrossing game on Sunday, ending Brazil's nine-match winning run in World Cup qualifiers.
Chile and Bolivia have the chance to get back into World Cup contention with two crucial home games over the next few days.
Brazil are leading the way in CONMEBOL qualifying, but what about the rest as this week's tripleheaders see two-thirds of games complete?
The suspension of Argentina vs. Brazil took the spotlight off a competitive South American World Cup qualifying, but all eyes are back on the pitch.
South American players are in a club-vs.-country tug of war, a situation made worse by CONMEBOL's insistence on playing this year's Copa America.
Radamel Falcao has joined Rayo Vallecano on a free transfer after his contract with Galatasaray was terminated.
Substitute Fernando Saucedo scored a stunning late goal to give home side Bolivia a 1-1 draw against Colombia in their World Cup qualifier.
Brazil are comfortably out front of South America's World Cup qualifying campaign, but behind them, a lot could change between now and Qatar 2022.
Luis Diaz scored a second-half double, the second an unstoppable 25-metre strike in injury time, to give Colombia a 3-2 win over Peru on Friday.
Lionel Messi mocked Yerry Mina, telling him to "Dance now," as Argentina beat Colombia on penalties to set up a Copa America final against Brazil.
Argentina will face Brazil in the Copa America final after they beat Colombia 3-2 in a shootout on Tuesday following a 1-1 draw in their semifinal.
The 3-0 result flattered Argentina, but Leo Messi was once again pivotal for his nation. Colombia, meanwhile, edged past Uruguay without a No. 10.
David Ospina saved two penalties in a shootout to give Colombia victory over Uruguay and a place in the Copa America semifinals on Saturday.
Will Neymar lead Brazil to another Copa America crown, or will Lionel Messi finally win his first senior international title with Argentina?
Neymar is in form, Leo Messi is breaking records, but it's the displays of Ricardo Gareca's Peru that have been the talk of the Copa group stage.
The Colombian Football Federation (FCF) has asked Copa America organisers to suspend the referee from their 2-1 defeat by Brazil.
Brazil beat Colombia 2-1 in Copa America action on Casemiro's header deep into stoppage time.
Uruguay's Facundo Torres and Ecuador's Gonzalo Plata may be inconsistent, but they are making people sit up and take notice at the Copa America.
There were 140 known COVID-19 cases at the Copa America in Brazil on Monday, up from 66 positive tests on Thursday.
Yerry Mina's own goal in the second half saw Colombia crash to a 2-1 defeat by Peru in an absorbing Copa America clash on Sunday.
The second set of Copa America matches saw Argentina get their first win of the tournament while hosts Brazil scored another big victory.
An understrength Venezuela shut out a vastly superior Colombia in a 0-0 draw in the Copa America on Thursday.