The U.S. or Mexico could face a winner-takes-all match against a team from Oceania if either side doesn't directly qualify for the World Cup.
LA Galaxy have taken a dig at Mexico's Gerardo "Tata" Martino on social media after Tuesday's World Cup qualifying defeat in Canada.
Mexico's 2-1 defeat to Canada at Edmonton on Tuesday was the coldest match El Tri have played on record, according to multiple sources.
Mexico capped off a disappointing window with a 2-1 loss to Canada as the hosts ascended to the top spot of the CONCACAF table.
Mexico's Luis "Chaka" Rodriguez shared death threats sent to his wife on social media after Saturday's World Cup qualifier defeat to the USMNT.
It was a familiar score, but Weston McKennie and Christian Pulisic -- with help from 'The Man In The Mirror' -- made their mark against Mexico.
Christian Pulisic took a dig at Guillermo Ochoa by revealing a "man in the mirror" shirt -- a reference to the Mexico keeper's earlier statements.
Christian Pulisic and Weston McKennie both scored as the United States beat Mexico in a World Cup qualifier in Cincinnati, Ohio on Friday night.
United States men's national team manager Gregg Berhalter says that his side still has "a long way to go" to get the respect of rival Mexico.
The fandom between the U.S. and Mexico is complex, but for players who grew up in the middle of the rivalry, all that matters is food and family.
The U.S.-Mexico rivalry has increased off the pitch due to the ongoing efforts to sway dual national talent. For all, it is a very tough choice.
USMNT striker Ricardo Pepi said it will be a "special feeling" for him and his family in the stands when the U.S. takes on Mexico on Friday.
CONCACAF's biggest rivals meet again with World Cup qualifying points on the line. ESPN looks at the key players and storylines ahead of the game.
The U.S. and Mexico will always battle every time they meet given their rivalry, but this week's game might be the last to have so much at stake.
Mexico will face its last World Cup qualifiers of 2021 with a strong squad headlined by Napoli's Hirving Lozano and Wolves striker Raul Jimenez.
Christian Pulisic is back in the USMNT squad vs. Mexico and Jamaica, but Sergino Dest and Gio Reyna are set to miss out.